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SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 5 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
8
Vitamin B12's role in clotting
Nitrous Oxide-Induced Cerebral Venous Thrombosis: A Case Report, Potential Mechanisms, and Literature Review.
Addresses vitamin B12 and thrombosis
We observed a compelling case involving a 19-year-old female diagnosed with cerebral venous thrombosis (CVT) and intracerebral hemorrhage. This unusual situation stemmed from her history of nitrous oxide abuse, which led to a significant deficiency in vitamin B12. Nitrous oxide can interfere with vitamin B12's vital functions, particularly its role in breaking down homocysteine levels in the blood.
Our investigation revealed her serum vitamin B12 level was alarmingly low at less than 100 pg/mL, while her homocysteine levels soared to 100.6 µmol/L, far exceeding the normal range. After she began vitamin B12 supplementation, we were pleased to see her vitamin B12 levels return to normal, along with a drastic reduction in homocysteine.
This case highlights an essential connection: low vitamin B12 levels may contribute to hyperhomocysteinemia, which in turn could play a significant role in the formation of blood clots. While there were no other thrombophilia risk factors found, the evidence suggests that restoring vitamin B12 levels through supplementation can positively impact homocysteine levels and reduce the risk of clotting problems.
Overall, this finding underscores how important vitamin B12 is in maintaining healthy blood clotting mechanisms.
Our investigation revealed her serum vitamin B12 level was alarmingly low at less than 100 pg/mL, while her homocysteine levels soared to 100.6 µmol/L, far exceeding the normal range. After she began vitamin B12 supplementation, we were pleased to see her vitamin B12 levels return to normal, along with a drastic reduction in homocysteine.
This case highlights an essential connection: low vitamin B12 levels may contribute to hyperhomocysteinemia, which in turn could play a significant role in the formation of blood clots. While there were no other thrombophilia risk factors found, the evidence suggests that restoring vitamin B12 levels through supplementation can positively impact homocysteine levels and reduce the risk of clotting problems.
Overall, this finding underscores how important vitamin B12 is in maintaining healthy blood clotting mechanisms.
Read More
9
Vitamin B12's role in clot management
A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report.
Moderate relevance to findings
We examined a fascinating case involving a 25-year-old male who experienced severe headaches and vertigo due to cerebral venous thrombosis (CVT). This unique situation arose after the patient had been abusing nitrous oxide, leading to a vitamin B12 deficiency.
After arriving at the hospital, he underwent a set of examinations which raised suspicions of a cerebrovascular accident. A CT scan and subsequent MRI confirmed the presence of clotting in the brain’s venous structures. His unusually high levels of homocysteine and low vitamin B12 pointed directly to a deficiency as a contributing factor to the blood clot.
Treatment for the patient included vitamin B12 supplementation alongside anticoagulants. Remarkably, within just a week, we saw significant improvement in his symptoms. This case underscores the potential importance of vitamin B12 in managing conditions associated with blood clotting, especially in individuals with deficiencies.
While vitamin B12 treatment was part of the regimen, it’s crucial to note that it was not administered in isolation but rather alongside other medications. This complicates our ability to draw definitive conclusions about its individual effectiveness in this specific scenario.
After arriving at the hospital, he underwent a set of examinations which raised suspicions of a cerebrovascular accident. A CT scan and subsequent MRI confirmed the presence of clotting in the brain’s venous structures. His unusually high levels of homocysteine and low vitamin B12 pointed directly to a deficiency as a contributing factor to the blood clot.
Treatment for the patient included vitamin B12 supplementation alongside anticoagulants. Remarkably, within just a week, we saw significant improvement in his symptoms. This case underscores the potential importance of vitamin B12 in managing conditions associated with blood clotting, especially in individuals with deficiencies.
While vitamin B12 treatment was part of the regimen, it’s crucial to note that it was not administered in isolation but rather alongside other medications. This complicates our ability to draw definitive conclusions about its individual effectiveness in this specific scenario.
Read More
9
Vitamin B-12 resolves clotting disorders
Life-Threatening Microangiopathy or Vitamin Deficiency: A Case Report of the Clinical Manifestations of Pseudo-Thrombotic Microangiopathic Anemia.
Indicates significance of vitamin B-12
We encountered a compelling case that sheds light on the relationship between vitamin B-12 deficiency and a condition known as pseudo-thrombotic microangiopathic anemia. This condition often mimics more severe blood disorders requiring aggressive treatments. However, during this case, we observed that addressing the deficiency with vitamin B-12 injections led to a significant improvement.
Our patient, a 51-year-old man, originally presented with symptoms like weakness and difficulty breathing, which raised alarms for potential blood issues. Upon extensive examination, he was found to have severe microangiopathic anemia with initial concerns pointing towards serious conditions like thrombotic thrombocytopenic purpura (TTP). Thankfully, after treatment with vitamin B-12 to combat the deficiency caused by pernicious anemia, the patient saw a marked recovery in both his symptoms and blood parameters.
This case highlights the importance of recognizing vitamin deficiencies as a potential cause of blood disorders. It demonstrates that what may appear to be serious hematological issues can sometimes be addressed with simple vitamin supplementation, likely saving patients from unnecessary invasive treatments.
Our patient, a 51-year-old man, originally presented with symptoms like weakness and difficulty breathing, which raised alarms for potential blood issues. Upon extensive examination, he was found to have severe microangiopathic anemia with initial concerns pointing towards serious conditions like thrombotic thrombocytopenic purpura (TTP). Thankfully, after treatment with vitamin B-12 to combat the deficiency caused by pernicious anemia, the patient saw a marked recovery in both his symptoms and blood parameters.
This case highlights the importance of recognizing vitamin deficiencies as a potential cause of blood disorders. It demonstrates that what may appear to be serious hematological issues can sometimes be addressed with simple vitamin supplementation, likely saving patients from unnecessary invasive treatments.
Read More
Most Useful Reviews
9.5
Reduced homocysteine levels
Vitamin B12 effectively reduces homocysteine, vital for cardiovascular health. My husband’s blood tests revealed his homocysteine levels decreased from 12 to 8 μmol/l after using this product, which indicates an impressive improvement. It's especially important for managing blood clot risks as we age. We intend to use it regularly.
Read More
9.5
Improved blood clotting
At 12, I found this treatment very helpful. My blood clotting has significantly improved.
Read More
8.5
Addressing blood clotting
This product has greatly helped me, especially noticeable by the third day. Many may have deficiencies in absorbing B12 and folic acid. Blood levels could appear normal yet remain low. It’s crucial to consider special forms of B12 and folic acid for conditions such as iron deficiency, neuralgia, and chronic fatigue, which can impact blood clotting.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
9
Vitamin B12's role in clot management
A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report.
Moderate relevance to findings
We examined a fascinating case involving a 25-year-old male who experienced severe headaches and vertigo due to cerebral venous thrombosis (CVT). This unique situation arose after the patient had been abusing nitrous oxide, leading to a vitamin B12 deficiency.
After arriving at the hospital, he underwent a set of examinations which raised suspicions of a cerebrovascular accident. A CT scan and subsequent MRI confirmed the presence of clotting in the brain’s venous structures. His unusually high levels of homocysteine and low vitamin B12 pointed directly to a deficiency as a contributing factor to the blood clot.
Treatment for the patient included vitamin B12 supplementation alongside anticoagulants. Remarkably, within just a week, we saw significant improvement in his symptoms. This case underscores the potential importance of vitamin B12 in managing conditions associated with blood clotting, especially in individuals with deficiencies.
While vitamin B12 treatment was part of the regimen, it’s crucial to note that it was not administered in isolation but rather alongside other medications. This complicates our ability to draw definitive conclusions about its individual effectiveness in this specific scenario.
After arriving at the hospital, he underwent a set of examinations which raised suspicions of a cerebrovascular accident. A CT scan and subsequent MRI confirmed the presence of clotting in the brain’s venous structures. His unusually high levels of homocysteine and low vitamin B12 pointed directly to a deficiency as a contributing factor to the blood clot.
Treatment for the patient included vitamin B12 supplementation alongside anticoagulants. Remarkably, within just a week, we saw significant improvement in his symptoms. This case underscores the potential importance of vitamin B12 in managing conditions associated with blood clotting, especially in individuals with deficiencies.
While vitamin B12 treatment was part of the regimen, it’s crucial to note that it was not administered in isolation but rather alongside other medications. This complicates our ability to draw definitive conclusions about its individual effectiveness in this specific scenario.
Read More
9
Vitamin B12 and blood clot relationship
Cerebral venous thrombosis associated with hyperhomocysteinemia and iron-deficiency anemia induced by autoimmune gastritis: A case report and literature review.
Combination therapy complicates assessment
We explored a case involving cerebral venous thrombosis (CVT) coinciding with hyperhomocysteinemia and iron-deficiency anemia, a condition attributed to autoimmune gastritis. The patient, a 47-year-old woman, presented with various symptoms including impaired movement and consciousness. Imaging tests revealed significant brain swelling and clot formations in the venous sinuses.
During the assessment, we noted that the patient suffered from anemia and elevated levels of homocysteine, both contributing factors to the development of blood clots. Interestingly, she also tested positive for intrinsic factor antibodies, leading to the diagnosis of autoimmune gastritis, which further compounded her condition.
Treatment for the patient included anticoagulants, as well as the replacement of iron and vitamin B12. Although the treatment approach effectively alleviated her symptoms and allowed for recovery without neurological deficits, it was difficult to isolate the specific impact of vitamin B12 on blood clot resolution since it was administered alongside other therapies.
Ultimately, while the combination of treatments was beneficial, the study does not provide clear evidence that vitamin B12 alone significantly contributes to the prevention or treatment of blood clots.
During the assessment, we noted that the patient suffered from anemia and elevated levels of homocysteine, both contributing factors to the development of blood clots. Interestingly, she also tested positive for intrinsic factor antibodies, leading to the diagnosis of autoimmune gastritis, which further compounded her condition.
Treatment for the patient included anticoagulants, as well as the replacement of iron and vitamin B12. Although the treatment approach effectively alleviated her symptoms and allowed for recovery without neurological deficits, it was difficult to isolate the specific impact of vitamin B12 on blood clot resolution since it was administered alongside other therapies.
Ultimately, while the combination of treatments was beneficial, the study does not provide clear evidence that vitamin B12 alone significantly contributes to the prevention or treatment of blood clots.
Read More
9
Vitamin B-12 resolves clotting disorders
Life-Threatening Microangiopathy or Vitamin Deficiency: A Case Report of the Clinical Manifestations of Pseudo-Thrombotic Microangiopathic Anemia.
Indicates significance of vitamin B-12
We encountered a compelling case that sheds light on the relationship between vitamin B-12 deficiency and a condition known as pseudo-thrombotic microangiopathic anemia. This condition often mimics more severe blood disorders requiring aggressive treatments. However, during this case, we observed that addressing the deficiency with vitamin B-12 injections led to a significant improvement.
Our patient, a 51-year-old man, originally presented with symptoms like weakness and difficulty breathing, which raised alarms for potential blood issues. Upon extensive examination, he was found to have severe microangiopathic anemia with initial concerns pointing towards serious conditions like thrombotic thrombocytopenic purpura (TTP). Thankfully, after treatment with vitamin B-12 to combat the deficiency caused by pernicious anemia, the patient saw a marked recovery in both his symptoms and blood parameters.
This case highlights the importance of recognizing vitamin deficiencies as a potential cause of blood disorders. It demonstrates that what may appear to be serious hematological issues can sometimes be addressed with simple vitamin supplementation, likely saving patients from unnecessary invasive treatments.
Our patient, a 51-year-old man, originally presented with symptoms like weakness and difficulty breathing, which raised alarms for potential blood issues. Upon extensive examination, he was found to have severe microangiopathic anemia with initial concerns pointing towards serious conditions like thrombotic thrombocytopenic purpura (TTP). Thankfully, after treatment with vitamin B-12 to combat the deficiency caused by pernicious anemia, the patient saw a marked recovery in both his symptoms and blood parameters.
This case highlights the importance of recognizing vitamin deficiencies as a potential cause of blood disorders. It demonstrates that what may appear to be serious hematological issues can sometimes be addressed with simple vitamin supplementation, likely saving patients from unnecessary invasive treatments.
Read More
8
Vitamin B12 impacts blood clot risk
Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification.
Moderate relevance based on findings
We explored the intriguing connection between Vitamin B12 deficiency and cerebral venous sinus thrombosis (CVST), a condition where blood clots block the brain's venous sinuses. In a case series involving three patients, we noticed a strong link between elevated levels of homocysteine, a condition known as hyperhomocysteinemia (hHcy), and CVST.
Each patient presented with persistent headaches, and two experienced additional symptoms like vision disturbances. Upon further investigation, we found that two of these individuals had particularly low Vitamin B12 levels. They were all treated with low-molecular-weight heparin, followed by anticoagulants, along with Vitamin B6, B9, and B12 supplements.
Encouragingly, all patients responded well to the treatment, with imaging showing resolution of the thrombosis in two cases. This suggests that we should consider hHcy seriously when evaluating CVST, particularly for individuals on a vegetarian diet, as many Indians primarily consume plant-based foods. The study implies that dietary Vitamin B12 fortification could play a crucial role in preventing such blood clot conditions.
Each patient presented with persistent headaches, and two experienced additional symptoms like vision disturbances. Upon further investigation, we found that two of these individuals had particularly low Vitamin B12 levels. They were all treated with low-molecular-weight heparin, followed by anticoagulants, along with Vitamin B6, B9, and B12 supplements.
Encouragingly, all patients responded well to the treatment, with imaging showing resolution of the thrombosis in two cases. This suggests that we should consider hHcy seriously when evaluating CVST, particularly for individuals on a vegetarian diet, as many Indians primarily consume plant-based foods. The study implies that dietary Vitamin B12 fortification could play a crucial role in preventing such blood clot conditions.
Read More
8
Biermer's Disease and Vitamin B12
Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report.
Vitamin B12 treatment evaluation
We examined the relationship between vitamin B12 treatment and blood clot formation in a patient diagnosed with Biermer's disease, a condition that causes severe vitamin B12 deficiency due to autoimmune factors. Our focus began with the patient’s unexplained neurological issues and deep vein thrombosis (DVT), prompting a closer look at how vitamin B12 plays a role in such complications.
The patient in this case was a 56-year-old man presenting with serious neurological symptoms like memory and gait disturbances, alongside a case of melena. Along with macrocytic anemia, he was diagnosed with DVT and signs of secondary dysautonomia. Following a thorough evaluation, which included blood work and imaging studies, the patient started receiving vitamin B12 supplementation.
We noted that while vitamin B12 was effectively addressing the anemia and other neurological symptoms, the study did not isolate the effect of vitamin B12 on the blood clot itself. The anticoagulant therapy was also a significant part of the treatment, suggesting that while vitamin B12 is crucial, it might not directly influence blood clot resolution.
Ultimately, the patient showed improvement in both clinical and biological aspects, highlighting the importance of vitamin B12 in managing the effects of Biermer's disease, though its specific impact on blood clots requires further investigation.
The patient in this case was a 56-year-old man presenting with serious neurological symptoms like memory and gait disturbances, alongside a case of melena. Along with macrocytic anemia, he was diagnosed with DVT and signs of secondary dysautonomia. Following a thorough evaluation, which included blood work and imaging studies, the patient started receiving vitamin B12 supplementation.
We noted that while vitamin B12 was effectively addressing the anemia and other neurological symptoms, the study did not isolate the effect of vitamin B12 on the blood clot itself. The anticoagulant therapy was also a significant part of the treatment, suggesting that while vitamin B12 is crucial, it might not directly influence blood clot resolution.
Ultimately, the patient showed improvement in both clinical and biological aspects, highlighting the importance of vitamin B12 in managing the effects of Biermer's disease, though its specific impact on blood clots requires further investigation.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.7
9.5
Improved blood clotting
At 12, I found this treatment very helpful. My blood clotting has significantly improved.
9.5
Reduced homocysteine levels
Vitamin B12 effectively reduces homocysteine, vital for cardiovascular health. My husband’s blood tests revealed his homocysteine levels decreased from 12 to 8 μmol/l after using this product, which indicates an impressive improvement. It's especially important for managing blood clot risks as we age. We intend to use it regularly.
Read More
8.5
Addressing blood clotting
This product has greatly helped me, especially noticeable by the third day. Many may have deficiencies in absorbing B12 and folic acid. Blood levels could appear normal yet remain low. It’s crucial to consider special forms of B12 and folic acid for conditions such as iron deficiency, neuralgia, and chronic fatigue, which can impact blood clotting.
Read More
7.5
Absorbing B-12 effectively
I wasn't confident in how well I assimilated B-12, given the common absorption issues. After a blood test, however, my B-12 levels have significantly improved since starting this supplement.
6.3
Positive blood test improvement
These lemon-flavoured tablets have led to an improvement in my blood tests. They contain high-quality methylcobalamin and dissolve easily. While I might not order again solely for taste, the results are encouraging.
